| 摘要 |
［Objectives］To observe the clinical efficacy of Dingjing Pills on patients with schizophrenia accompanied by risky behaviors. [Methods] Two hundred patients diagnosed with schizophrenia and risky behaviors were divided into two groups based on the random and double-blinded principle: the treatment group (100 cases) treated with Dingjing Pills combined with risperidone, and the control group (100 cases) treated with risperidone alone. The observation course was 6 weeks. The clinical efficacy was compared using brief psychiatric rating scale (BPRS), modified overt aggression scale (revised edition) (MAOS), treatment emergent symptom scale (TESS), and blood routine, liver function, kidney function, and electrocardiogram examinations were conducted. [Results] After treatment, Dingjing Pills significantly reduced the scores of brief psychiatric rating scale, modified overt aggression scale and treatment emergent symptom scale in patients with schizophrenia and dangerous behaviors, and had no significant toxic or side effects. The total effective rate in the treatment group was 88.8%, while the total effective rate in the control group was 77.1%. There was a significant difference in therapeutic efficacy between the two groups (P<0.05). [Conclusions] Dingjing Pills has an intervention and therapeutic effect on high-risk behaviors of schizophrenia, with minimal side effects and easy acceptance by patients. |
