| 刊名 | Medicinal Plant |
| 作者 | Yunfeng BAI，Yuxin HANG，Ning XU，Jinglin LIU，Liang XU |
| 作者单位 | College of Chemistry and Materials Science, Inner Mongolia Minzu University/Key Laboratory of Natural Product Chemistry and Functional Molecular Synthesis of Inner Mongolia Autonomous Region |
| DOI | 10.19601/j.cnki.issn2152-3924.2023.04.007 |
| 年份 | 2023 |
| 刊期 | 4 |
| 页码 | 27-30，45 |
| 关键词 | Network pharmacology, Capsicum, Type 2 diabetes mellitus, Mechanism of action |
| 摘要 | [Objectives] The paper was to explore the mechanism of capsicum (Capsicum annuum L.) in treating type 2 diabetes mellitus (T2DM) and search for new targets. [Methods] The active ingredients of capsicum were queried from TCMSP database to obtain the corresponding target proteins. The related targets of T2DM were screened from GeneCards database, and the target intersection of active ingredients of capsicum and diabetes mellitus was obtained via Venny software. The protein-protein interaction (PPI) network of the compounds was constructed using STRING database, and the GO bio-function and KEGG pathway enrichment were further analyzed using Metascape database. [Results] Through TCMSP database query and conditional screening, 14 candidate active molecules, 93 potential targets and 225 related pathways were obtained. [Conclusions] The results of GO and KEGG enrichment analysis show that the main active ingredients of capsicum play a role in the treatment of T2DM by regulating cancer pathways, chemical carcinogenesis—receptor activation, proteoglycans in cancer, and prostate cancer pathways, which will provide an important theoretical basis for subsequent research. |
