| 刊名 | Agricultural Biotechnology |
| 作者 | Hongyan WU1#, Keyi ZHOU1#, Chunmei LI1, Hong XUE1, Bincan MENG1, Jie LAN1, Jialong LU1, Zhenxiu LIU1,2,3, Yangpeng SHI1, Yihe WEI1, Yiting YANG1,Jingyi JIANG1, Xin JIANG3*, Zhiqiang CHEN3*, Dengfeng ZOU1,2* |
| 作者单位 | 1. College of Pharmacy, Guilin Medical University, Guilin, 541199, China; 2. Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education; Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Nanning 530021, China; 3. Guangxi Clinical Medical Research Center for Neurological Diseases, First Affiliated Hospital of Guilin Medical University, Guilin, 541001,China |
| DOI | DOI:10.19759/j.cnki.2164-4993.2026.02.010 |
| 年份 | 2026 |
| 刊期 | 2 |
| 页码 | 49-60,68 |
| 关键词 | Photodynamic; Anti-cancer; Reactive oxygen species; Photosensitizer; Mechanism |
| 摘要 | Photodynamic therapy (PDT) is an emerging cancer treatment modality that induces tumor cell death by utilizing photosensitizers generating reactive oxygen species (ROS) under specific wavelength light excitation, which has the advantages of high selectivity and low toxicity. This paper reviews the latest research advances and challenges in PDT for cancer treatment. It focuses on analyzing its fundamental principles and mechanisms, including Type I and Type II photodynamic reactions, the intracellular localization and mechanisms of photosensitizers, and thoroughly explores various PDT-induced cell death patterns, especially the challenges and corresponding strategies related to the tumor microenvironment (TME). Meanwhile, this paper elaborates the main mechanisms of tumor cell resistance to PDT and discusses the synergistic mechanisms to overcome these challenges through novel photosensitizers, nanocarrier technology and multimodal combined other therapies like photothermal therapy, chemotherapy, immunotherapy and others. This review aims to reveal the complexity and diversity of PDT mechanisms, assess current challenges, and look toward the future, so as to provide a deep understanding and theoretical foundation for further exploration in the field of PDT, and promote the further development and clinical application of PDT in the field of cancer treatment. |
