| 刊名 | Agricultural Biotechnology |
| 作者 | Chengzhang LIN;Yanling LIAO;Jiao CHEN;Bingmiao GAO |
| 作者单位 | Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, Hainan Medical University |
| DOI | DOI:10.19759/j.cnki.2164-4993.2023.06.020 |
| 年份 | 2023 |
| 刊期 | 6 |
| 页码 | 99-105 |
| 关键词 | μ-Conotoxins; voltage-gated sodium channel; homologous modeling; structure-activity relationship |
| 摘要 | The voltage-gated sodium channel(Na v)is widely present in mammals and can generate cell action potentials,which are related to many diseases.Theμ-Conotoxins(μ-CTx)isolated from the venom of cone snails can specifically block the voltage-gated sodium channel;it can be widely used as a necessary probe to distinguish the Na v channel subtypes.In this study,the effects of eightμ-CTx on different Na v channel isoforms were reviewed,and sequence alignment and protein homologous modeling were used to predict their biological activities,and the structure-activity relationship betweenμ-CTx and mutagenesis strategies. |
