| 刊名 | Agricultural Biotechnology |
| 作者 | Zhe FENG, Pan DENG, Yuehan LIU, Junqing WANG* |
| 作者单位 | College of Biological Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China |
| DOI | DOI:10.19759/j.cnki.2164-4993.2024.03.014 |
| 年份 | 2024 |
| 刊期 | 3 |
| 页码 | 55-59,63 |
| 关键词 | D-Psicose; Biosynthesis; High-throughput screening |
| 摘要 | possesses high solubility, antioxidant activity, anti-inflammatory properties, and the ability to regulate cholesterol levels and enhance insulin sensitivity. However, D-psicose is relatively scarce in nature, making large-scale extraction and utilization impractical. Consequently, the development of cost-effective synthetic strategies for D-psicose is pivotal for its industrial application. In recent years, the Izumoring strategy has emerged as an efficient alternative to chemical synthesis for producing D-psicose. Nonetheless, limitations in the biotransformation of D-psicose, primarily governed by the conversion rate of D-psicose 3-epimerase (DPEase) and enzyme yield, continue to pose challenges in achieving economically viable production. Enzyme engineering and the establishment of high-level expression systems remain crucial avenues for reducing the overall biosynthesis costs. |
