| 刊名 | Medicinal Plant |
| 作者 | Huang YANG， Xingjun CHEN， Yan LIN |
| 作者单位 | State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University； Engineering Research Center of Authentic Medicinal Materials for Chronic Disease Prevention and Treatment under Guizhou Provincial Department of Education |
| DOI | 10.19601/j.cnki.issn2152-3924.2025.03.009 |
| 年份 | 2025 |
| 刊期 | 3 |
| 页码 | 32-35 |
| 关键词 | Sophora flavescens, Kurarinol A (KA), TGF/Smad signaling pathway, Anti-hepatic fibrosis |
| 摘要 | ［Objectives］ To investigate the anti-hepatic fibrosis mechanism of lavandulyl flavonoid Kurarinol A (KA) from Sophora flavescens through the TGF/Smad signaling pathway. [Methods] A hepatic fibrosis model was established by TGF-β1-induced activation of human hepatic stellate cells LX-2. Western blot and RT-qPCR techniques were employed to study the anti-fibrotic mechanism of KA through the TGF/Smad signaling pathway. [Results] KA exerted anti-hepatic fibrosis effects by significantly reducing the gene expression levels of TGF-β1, Smad2, Smad3, and Smad4, as well as markedly decreasing the protein expression levels of TGF-β1, p-Smad2/3/Smad2/3, and Smad4. [Conclusions] KA demonstrates significant anti-hepatic fibrosis activity and alleviates liver fibrosis through the TGF/Smad signaling pathway. |
