| 刊名 | Medicinal Plant |
| 作者 | Miaoxin ZHANG， Yunjiao YUAN， Chen YANG， Jinfeng CHEN |
| 作者单位 | Shaanxi University of Chinese Medicine； Shaanxi Provincial Hospital of Traditional Chinese Medicine |
| DOI | 10.19601/j.cnki.issn2152-3924.2025.03.022 |
| 年份 | 2025 |
| 刊期 | 3 |
| 页码 | 80-83 |
| 关键词 | Gastrodiae Rhizoma (Tianma), Uncariae Ramulus Cum Uncis (Gouteng), Drug pair, Hypertension |
| 摘要 | Based on multidisciplinary research methods, this study analyzes the mechanisms and potential of Gastrodiae Rhizoma (Tianma) and Uncariae Ramulus Cum Uncis compatibility in treating hypertension. The research confirms that components including rhynchophylline and gastrodin exert antihypertensive effects by inhibiting vascular smooth muscle proliferation and modulating calcium signaling pathways. The combination of these two herbs enhances the bioavailability of core components, synergistically regulates targets such as PTGS2 and NOS3, activates the PPAR signaling pathway, and strengthens vasodilation and antioxidant capacity. Clinical studies demonstrate that Tianma Gouteng Decoction exhibits superior efficacy in improving mitochondrial function and delaying vascular aging compared to single components. This investigation provides scientific evidence for the multi-target antihypertensive effects of traditional Chinese medicine and promotes its modern application in cardiovascular disease treatment. |
