| 刊名 | Medicinal Plant |
| 作者 | Linhao LIU, Mengjia LI, Mingfen LI, Yue ZHAO, Kunyan ZOU, Yifei CHEN* |
| 作者单位 | College of Pharmacy, Guilin Medical University, Guilin 541199, China; Guangxi Key Laboratory of Drug Discovery and Optimization, Guilin 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Drug Property Evaluation, Guilin Medical University, Guilin 541199, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.010.014 |
| 年份 | 2026 |
| 刊期 | 1 |
| 页码 | 61-64 |
| 关键词 | Huanglian Jiedu Decoction (HLJDD), Porphyromonas gingivalis, Alzheimer’s disease (AD), Novel object recognition, Neuroinflammation |
| 摘要 | [Objectives] To investigate the ameliorative effects of Huanglian Jiedu Decoction (HLJDD) on cognitive function impairment in an Alzheimer’s disease (AD) mouse model induced by Porphyromonas gingivalis infection. [Methods] Thirty-six male C57BL/6 mice were randomly assigned to six groups: control group, model group, low-dose HLJDD group, medium-dose HLJDD group, high-dose HLJDD group, and positive drug group (treated with moxifloxacin). With the exception of the control group, all groups underwent an 8-week P. gingivalis chronic infection model induced via oral administration. Subsequently, each treatment group received corresponding doses of HLJDD (2.5, 5, and 10 mg/g) or moxifloxacin for 8 week intervention. The novel object recognition test was employed to evaluate the non-spatial memory abilities of mice, and the novel object exploration preference index was calculated to assess cognitive function. [Results] Compared to the control group, the novel object exploration preference index of mice in the model group was significantly reduced (P<0.01), indicating that P. gingivalis infection effectively induced cognitive impairment. Relative to the model group, mice treated with medium and high doses of HLJDD exhibited a significant, dose-dependent increase in the novel object exploration preference index, whereas the low-dose group showed no significant improvement. Additionally, the positive drug moxifloxacin demonstrated a significant neuroprotective effect on cognition. [Conclusions] HLJDD effectively improves cognitive function impairment in AD model mice induced by P. gingivalis infection, offering novel experimental evidence supporting the heat-clearing and detoxification approach as well as the therapeutic potential of traditional Chinese medicine (TCM) compounds in the intervention of AD. |
