| 刊名 | Medicinal Plant |
| 作者 | Qiannan FU |
| 作者单位 | Affiliated Hospital of Shanxi University of Chinese Medicine, Taiyuan 030000, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.010.017 |
| 年份 | 2026 |
| 刊期 | 1 |
| 页码 | 78-82 |
| 关键词 | Diarrhea-predominant irritable bowel syndrome, Gut microbiota, Bile acids, Interaction mechanisms, Research progress |
| 摘要 | This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies. It elaborates on the biosynthetic and metabolic pathways of bile acids, the phenotypes of bile acid dysregulation in IBS-D patients, and the related pathogenic molecular mechanisms. A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids, specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence, this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D. It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis. |
