| 刊名 | Medicinal Plant |
| 作者 | Bingting LI, Xuefeng LI* |
| 作者单位 | Department of Endocrinology, Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine, Shiyan 442000, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.010.013 |
| 年份 | 2026 |
| 刊期 | 1 |
| 页码 | 57-60 |
| 关键词 | Psoriasis, Mental disorders, Major depressive disorder, Bipolar disorder, Mendelian randomization |
| 摘要 | [Objectives] To investigate the potential causal relationship between psoriasis and common mental disorders, and to provide genetic epidemiological evidence for the early intervention of mental comorbidities. [Methods] Based on publicly available large-scale GWAS data, a bidirectional Mendelian randomization (MR) approach was employed to assess the causal associations between psoriasis and major depressive disorder (MDD), bipolar disorder, schizophrenia, and anxiety disorders. The inverse variance weighted (IVW) method served as the primary analytical tool, supplemented by sensitivity analyses using MR-Egger and weighted median methods. Additionally, a subgroup analysis was conducted for psoriatic arthritis (PsA). [Results] Forward MR analysis revealed a significant positive causal association between the genetic predisposition to psoriasis and bipolar disorder as well as MDD, whereas no significant causal relationship was observed with schizophrenia or anxiety disorders. The reverse MR analysis found no causal effect of mental disorders on psoriasis. Subgroup analysis of PsA indicated that its genetic predisposition was significantly associated with the risk of bipolar disorder. The results of various sensitivity analyses and pleiotropy tests supported the robustness of the conclusions. [Conclusions] This study provides genetic evidence supporting a causal link between psoriasis and both MDD and bipolar disorder. In particular, patients with PsA are at a higher risk of developing bipolar disorder, highlighting the need to strengthen early screening and intervention for mental health in clinical management. |
